AlphaFold2 has revolutionized bioinformatics, but its ability to predict protein structures with high accuracy comes at the price of a costly database search for multiple sequence alignments. Fang and colleagues pre-train a large-scale protein language model and use it in conjunction with AlphaFold2 as a fully trainable and efficient model for structure prediction.
- Xiaomin Fang
- Fan Wang
- Le Song
