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Showing 1–2 of 2 results
Advanced filters: Author: Yingyi Cong Clear advanced filters

  • The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

    • Miao Mei
    • Yang Yang
    • Xu Tan
    Research
    Nature Microbiology
    P: 1-15

  • CRISPR-Cas9 is widely used for genome engineering but structural data for the DNA cleavage step are still incomplete. Here, the authors present the cryo-EM structure of a ternary Cas9-sgRNA-target DNA complex, perform MD simulations and discuss implications for the Cas9 DNA cleavage mechanism.

    • Cong Huai
    • Gan Li
    • Qiang Huang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9