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Showing 1–8 of 8 results
Advanced filters: Author: Yingyuan Sun Clear advanced filters

  • The mitochondrial pyruvate carrier (MPC) transports pyruvate into the mitochondrial matrix. Here, authors present cryo-EM structures of human MPC1-2 in IMS-open and inhibitor-bound matrix-open states, revealing transport and inhibition mechanisms.

    • Yingyuan Sun
    • Yaru Wang
    • Xiaofeng Qi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Cryo-electron microscopy structures of human Porcupine in complex with palmitoleoyl-coenzyme A, the inhibitor LGK974 and its peptide substrate suggest a mechanism for Wnt acylation.

    • Yang Liu
    • Xiaofeng Qi
    • Xiaochun Li
    Research
    Nature
    Volume: 607, P: 816-822

  • Nucleocytoplasmic large DNA viruses are a group of viruses that infect many eukaryotic hosts. Here, the authors provide a 3.5 Å resolution icosahedrally-averaged capsid structure of Paramecium bursaria chlorella virus 1 and show how 1800 minor capsid proteins form a hexagonal network below the outer capsid shell.

    • Qianglin Fang
    • Dongjie Zhu
    • Michael G. Rossmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The vacuolar-type H+ -ATPases (V-ATPase) hydrolyze ATP to pump protons across the plasma or intracellular membrane. Here authors report two cryo-EM structures of the intact V-ATPase from bovine brain with all the subunits including the subunit H, which is essential for ATPase activity.

    • Rong Wang
    • Tao Long
    • Xiaochun Li
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open state trimers.

    • Neeti Ananthaswamy
    • Qianglin Fang
    • Venigalla B. Rao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Sun and Li propose and validate a model for cholesterol engagement and transport via the ATP-binding cassette transporter ABCA1, via generating and comparing high-resolution cryo-EM structures of three distinct states of the transporter: with and without ATP and a mutant form unable to export cholesterol that is relevant to human pathology

    • Yingyuan Sun
    • Xiaochun Li
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 238-245