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Showing 1–6 of 6 results
Advanced filters: Author: Yinxiu Zhan Clear advanced filters

  • Germ layer specification during zygotic genome activation is regulated by chromatin state. Here, the authors use single-cell multiome profiling in Drosophila to show that H3K27me3 and H3K27ac at cis-regulatory elements control cell type-specific gene expression and developmental progression.

    • Francesco Cardamone
    • Annamaria Piva
    • Nicola Iovino
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Live-cell imaging shows that interactions within topologically associating domains are transient and frequent throughout the cell cycle. Convergent CTCF sites regulate the frequency and duration of interactions, which last a few minutes on average.

    • Pia Mach
    • Pavel I. Kos
    • Luca Giorgetti
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1907-1918

  • The transcriptional effect of an enhancer depends on its contact probabilities with the promoter through a nonlinear relationship, and enhancer strength determines absolute transcription levels as well as the sensitivity of a promoter to CTCF-mediated transcriptional insulation.

    • Jessica Zuin
    • Gregory Roth
    • Luca Giorgetti
    ResearchOpen Access
    Nature
    Volume: 604, P: 571-577