Nature Search

Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression

The role of protein UFMylation in cancer remains to be understood. Here the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation in breast cancer cells, which could be therapeutically targeted by a cell-penetrating peptide through disrupting UFL1-AKT interaction.

Xiao Yang
Yalei Wen
Tongzheng Liu
ResearchOpen Access20 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human

A new computational method coupled with a CRISPR–Cas12a screen identifies human long noncoding RNAs (lncRNAs) that lead to cell proliferation defects, which can be rescued by zebrafish homologs. Knockdown of four zebrafish lncRNAs that perturb embryonic development can be rescued by human homologs.

Wenze Huang
Tuanlin Xiong
Qiangfeng Cliff Zhang
ResearchOpen Access09 Jan 2024
Nature Genetics

Volume: 56, P: 124-135
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Jian Q Feng
Leanne M Ward
Kenneth E White
Research08 Oct 2006
Nature Genetics

Volume: 38, P: 1310-1315
CD8⁺ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients

Haifeng Lin
Yi Han
Hezhe Lu
ResearchOpen Access09 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-10
Spontaneous hyperactivity in Ash1l mutant mice, a new model for Tourette syndrome

Shiguo Liu
Miaomiao Tian
Ji-Song Guan
Research21 Jan 2020
Molecular Psychiatry

Volume: 25, P: 241-242
Entanglement-enhanced optomechanical sensing

Joint force measurements with entangled optical probes on two optomechanical sensors are demonstrated. The force sensitivity is improved by 40% in the shot-noise-dominant regime. The sensing bandwidth is improved by 20% in the thermal noise limit.

Yi Xia
Aman R. Agrawal
Zheshen Zhang
Research20 Apr 2023
Nature Photonics

Volume: 17, P: 470-477
CDK4/6-mediated phosphorylation of DUB3 promotes YAP1 stability and hepatocellular carcinoma progression

Lei Huang
Wenying Yuan
Yingjie Zhu
ResearchOpen Access30 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-12
CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Lei Huang
Yalei Wen
Tongzheng Liu
ResearchOpen Access18 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-14
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

Xu Wu
Yixia Jiang
Xiaowu Tan
ResearchOpen Access30 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-16
Mutations in ASH1L confer susceptibility to Tourette syndrome

Shiguo Liu
Miaomiao Tian
Ji-Song Guan
Research31 Oct 2019
Molecular Psychiatry

Volume: 25, P: 476-490
USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation

Xiaosheng Wu
Hao Wang
Side Liu
ResearchOpen Access20 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-11

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Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression

Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

CD8⁺ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients

Spontaneous hyperactivity in Ash1l mutant mice, a new model for Tourette syndrome

Entanglement-enhanced optomechanical sensing

CDK4/6-mediated phosphorylation of DUB3 promotes YAP1 stability and hepatocellular carcinoma progression

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

Mutations in ASH1L confer susceptibility to Tourette syndrome

USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation

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