Defects in mitochondrial function have been believed to contribute to insulin resistance. Myung-Shik Lee and colleagues now show that mitochondrial dysfunction in muscle induced by tissue-specific deficiency of autophagy results in upregulation of Fgf21 and improved metabolism, suggesting that at least some mitochondrial dysfunction may actually be beneficial.
- Kook Hwan Kim
- Yeon Taek Jeong
- Myung-Shik Lee
