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Showing 1–6 of 6 results
Advanced filters: Author: Yodai Takei Clear advanced filters

  • In this Tools of the Trade article, Yodai Takei presents two-layer seqFISH+, an imaging method that uses a novel barcoding strategy to simultaneously profile chromatin organization, the transcriptome and subnuclear structures at single-cell resolution.

    • Yodai Takei
    Research Highlights
    Nature Reviews Genetics
    Volume: 26, P: 582-583

  • A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mouse brain.

    • Yodai Takei
    • Yujing Yang
    • Long Cai
    Research
    Nature
    Volume: 641, P: 1037-1047

  • Multiplexed imaging of 3,660 chromosomal loci in individual mouse embryonic stem cells by DNA seqFISH+ with immunofluorescence of 17 chromatin marks and subnuclear structures reveals invariant organization of loci within individual cells, and heterogeneous and long-lived distinct combinatorial chromatin states in cellular subpopulations.

    • Yodai Takei
    • Jina Yun
    • Long Cai
    Research
    Nature
    Volume: 590, P: 344-350

  • seqFISH+, an evolution of sequential fluorescence in situ hybridization with super-resolution imaging capabilities, is used to image mRNAs of 10,000 genes in cultured cells and mouse brain slices, demonstrating the ability to generate spatial atlases and to perform discovery-driven studies in situ.

    • Chee-Huat Linus Eng
    • Michael Lawson
    • Long Cai
    Research
    Nature
    Volume: 568, P: 235-239