Temperature-responsive (or thermoresponsive) polymers belong to the most studied class of smart polymers and are mainly classified into two types based on their temperature-responsive behavior: lower critical solution temperature (LCST) and upper critical solution temperature (UCST). Based on polymeric design, when more than two temperature-responsive segments are connected through a covalent bond, the block copolymers are expected to show a multi-temperature-responsive property upon conformational changes. This review focuses on current multi-temperature-responsive polymeric materials and their future applications such as drug-delivery carriers, sensors in solvents, model proteins, and memory storage.