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Showing 1–4 of 4 results

Advanced filters: Author: Yoichi Kurumida Clear advanced filters

Extensive antibody search with whole spectrum black-box optimization

Andrejs Tučs
Tomoyuki Ito
Koji Tsuda
ResearchOpen Access04 Jan 2024
Scientific Reports

Volume: 14, P: 1-7
A rational blueprint for the design of chemically-controlled protein switches

Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.

Sailan Shui
Pablo Gainza
Bruno E. Correia
ResearchOpen Access01 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

The natural product fucoxanthinol causes G1 arrest through decreasing the levels of ribosomal protein uS7, which directly binds and stabilises cyclin-dependent kinase 6.

Yosuke Iizumi
Yoshihiro Sowa
Toshiyuki Sakai
ResearchOpen Access09 Jun 2022
Communications Biology

Volume: 5, P: 1-11
Predicting antibody affinity changes upon mutations by combining multiple predictors

Yoichi Kurumida
Yutaka Saito
Tomoshi Kameda
ResearchOpen Access11 Nov 2020
Scientific Reports

Volume: 10, P: 1-9