During fasting, animals shift their energy source from carbohydrates to triglycerides. Here, Izumida et al. report that glycogen shortage in the liver activates a liver–brain–adipose-tissue neurocircuit that signals the switch in fuel source from liver glycogen to triglycerides in fat cells.
- Yoshihiko Izumida
- Naoya Yahagi
- Hitoshi Shimano
