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Showing 1–18 of 18 results
Advanced filters: Author: Yonatan H. Grad Clear advanced filters

  • Population-level distributions of SARS-CoV-2 viral load can correlate with epidemic trends. Here, the authors use viral loads to nowcast epidemic growth rates over two-week periods and investigate how the relationship varies by peak viral load, viral dynamics, and sampling approaches.

    • Tse Yang Lim
    • Sanjat Kanjilal
    • James A. Hay
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • New York City is one of the areas most affected by the SARS-CoV-2 pandemic in the United States, and there has been large variation in rates of hospitalisation and death by city borough. Here, the authors show that boroughs with the largest reduction in daily commutes also had the lowest SARS-CoV-2 prevalence.

    • Stephen M. Kissler
    • Nishant Kishore
    • Yonatan H. Grad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.

    • Kevin C. Ma
    • Tatum D. Mortimer
    • Yonatan H. Grad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Phylogeographical genomic analysis of Neisseria gonorrhoeae uncovers its recent emergence and current distribution into two distinct lineages that are differentially associated with antibiotic resistance and sexual networks.

    • Leonor Sánchez-Busó
    • Daniel Golparian
    • Simon R. Harris
    Research
    Nature Microbiology
    Volume: 4, P: 1941-1950

  • In this study, the authors compare the viral kinetics of first and second SARS-CoV-2 infections using data from an occupational surveillance scheme in the National Basketball League. They find that second infections tend to have a faster clearance time, and that clearance times in first and second infections were positively correlated.

    • Stephen M. Kissler
    • James A. Hay
    • Yonatan H. Grad
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7

  • The mechanisms underlying resistance of Neisseria gonorrhoeae to the antibiotic azithromycin are incompletely understood. Here, Ma et al. conduct a conditional genome-wide association study to identify new resistance mutations and experimentally confirm that a mutation in ribosomal protein L4 confers increased resistance.

    • Kevin C. Ma
    • Tatum D. Mortimer
    • Yonatan H. Grad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Here, Williamson et al. combine epidemiological and genomic analysis of 2,186 Neisseria gonorrhoeae isolates from Australia and show that men who have sex with men and women are a possible ‘bridging’ population between men who have sex with men and heterosexuals.

    • Deborah A. Williamson
    • Eric P. F. Chow
    • Benjamin P. Howden
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Genomic neighbour typing can be used to infer the antimicrobial susceptibility and resistance of a bacterial sample based on the genomes of closest relatives. Combined with MinION sequencing, it can rapidly determine microbial resistance for clinical samples within 4 h.

    • Karel Břinda
    • Alanna Callendrello
    • William P. Hanage
    ResearchOpen Access
    Nature Microbiology
    Volume: 5, P: 455-464

  • How does the discovery of SARS-CoV-2 cross-reactive T cells in unexposed individuals change our understanding of the COVID-19 pandemic? In this Perspective, the authors provide a thought experiment to explain why the discovery of cross-reactive T cells may affect disease severity in individuals, but is unlikely to change our estimate of the herd immunity threshold.

    • Marc Lipsitch
    • Yonatan H. Grad
    • Shane Crotty
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 709-713

  • We call upon the research community to standardize efforts to use daily self-reported data about COVID-19 symptoms in the response to the pandemic and to form a collaborative consortium to maximize global gain while protecting participant privacy.

    • Eran Segal
    • Feng Zhang
    • Paul Wilmes
    Comments & Opinion
    Nature Medicine
    Volume: 26, P: 1161-1165

  • The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes and demonstrate that a previously uncharacterized cellobiose PTS system is involved in central nervous system infection.

    • Yonatan H Grad
    • Sarah M Fortune
    News & Views
    Nature Genetics
    Volume: 48, P: 229-230

  • In this Perspective, Cobey, Larremore, Grad and Lipsitch argue that dose-sparing regimens of COVID-19 vaccines can reduce disease incidence, prevalence and burden and explain why they think that such strategies would also slow the rate of viral escape from vaccine or naturally induced immunity.

    • Sarah Cobey
    • Daniel B. Larremore
    • Marc Lipsitch
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 330-335

  • Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.

    • Jeremy E. Wilkinson
    • Eric A. Franzosa
    • Curtis Huttenhower
    Reviews
    Nature Medicine
    Volume: 27, P: 766-774

  • The Antimicrobial Resistance - Genomes, Big Data and Emerging Technologies Conference explored key topics including measuring the burden of AMR, global public health pathogen genomics infrastructure and surveillance, translation and implementation of genomics for AMR control, use of techniques such as wastewater surveillance, mathematical and statistical modelling, and Artificial Intelligence (AI) to aid understanding of AMR. This report describes research presented during plenary sessions and discussions, keynote presentations and posters.

    • Charlotte E. Chong
    • Thi Mui Pham
    • Kate S. Baker
    News & ViewsOpen Access
    npj Antimicrobials and Resistance
    Volume: 2, P: 1-6