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Showing 1–2 of 2 results
Advanced filters: Author: Yonatan Shapira Clear advanced filters

  • The liver is a heterogeneous organ organized in lobules that are radially polarized. The use of single-cell spatial transcriptomics has revealed that half of hepatic genes are differentially expressed across the lobule. Ben-Moshe et al. show how a multi-omics approach, which consists of transcriptomics, micro RNA profiling and proteomics, allows for characterization of liver heterogeneity with higher resolution.

    • Shani Ben-Moshe
    • Yonatan Shapira
    • Shalev Itzkovitz
    Research
    Nature Metabolism
    Volume: 1, P: 899-911

  • Chemically modifying proteins is hard to achieve selectively without purifying the target protein. Here, the authors present a method to modify proteins on lysine residues in living cells quicker than via known approaches and show that it can be used to develop protein covalent inhibitors.

    • Tomonori Tamura
    • Tsuyoshi Ueda
    • Itaru Hamachi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12