Nature Search

Genomic insights into historical improvement of heterotic groups during modern hybrid maize breeding

This study reports the genomic changes underlying the convergent and divergent agronomic improvement of the female and male heterotic groups during modern hybrid maize breeding, laying a foundation for the dissection and utilization of maize heterosis.

Chunhui Li
Honghui Guan
Haiyang Wang
Research18 Jul 2022
Nature Plants

Volume: 8, P: 750-763
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.

Lin Song
Shi Tang
Yifeng Du
ResearchOpen Access09 Apr 2019
Nature Communications

Volume: 10, P: 1-13
Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Liang Chen
Shun Zhang
Dali Li
Amendments and Corrections22 Apr 2024
Nature Chemical Biology

Volume: 20, P: 1094
Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma

The reasons for why hepatocellular carcinoma (HCC) is unresponsive to anti-PD-1 inhibition in some patients is not fully understood. Here the authors use human samples and mice tumour models to implicate serum amyloid A and STAT3 signalling involvement in the resistance to anti-PD1 immunotherapy in HCC.

Meng He
Yongxiang Liu
Ning Lyu
ResearchOpen Access26 Feb 2024
Nature Communications

Volume: 15, P: 1-19
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Yan Song
Bo Zhang
Jing Huang
ResearchOpen Access02 Feb 2023
Nature Medicine

Volume: 29, P: 473-482
Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling

Understanding the structure-function relationship in Cu-catalyzed CO₂ reduction is challenging due to dynamic active sites. This study introduces stable coordination polymer catalysts with homogenized, single-site Cu, enabling the study and tuning of C–C coupling efficiency in CO₂ electroreduction.

Yu Yang
Cheng Zhang
Fengwang Li
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-11
Author Correction: Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling

Yu Yang
Cheng Zhang
Fengwang Li
Amendments and CorrectionsOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1
Integrated multiomics signatures to optimize the accurate diagnosis of lung cancer

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Mengmeng Zhao
Gang Xue
Chang Chen
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer

Occult node metastasis is a key staging component of non-small cell lung cancer. Here, the authors use deep learning to improve diagnosis of lymph node metastasis from PET and CT radiomics.

Yifan Zhong
Chuang Cai
Yunlang She
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-14
Engineering a precise adenine base editor with minimal bystander editing

A precise adenine base editor variant, ABE9, was developed to generate single adenine transition at pathogenic homopolymeric adenine sites with minimal DNA/RNA off-target effects, suggesting promising potential for gene therapeutics.

Liang Chen
Shun Zhang
Dali Li
Research13 Oct 2022
Nature Chemical Biology

Volume: 19, P: 101-110
Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study

Ming Mao
Yiran Wei
Chengxuan Qiu
ResearchOpen Access02 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

The emergency of a high frequency of early memory T cells has been associated with clinical success of CAR T cell therapy. Here the authors show that target cancer cells stressed by disulfiram/copper complexes and ionizing radiation favour the reprogramming of CAR T cells that acquire memory-like characteristics, associated with prolonged anti-tumor response in preclinical solid tumor models.

Yufeng Wang
David L. Drum
Xinhui Wang
ResearchOpen Access15 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens

Jiafan Yang
Yongxiang Song
Jianhua Ju
Research16 Jan 2023
The Journal of Antibiotics

Volume: 76, P: 113-120
Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

Yongxiang Song
Jiafan Yang
Jianhua Ju
Research24 Apr 2020
The Journal of Antibiotics

Volume: 73, P: 542-547
PC3T: a signature-driven predictor of chemical compounds for cellular transition

PC3T is an in silico chemical screening pipeline to identify small-molecule treatments that induce cell state transitions for any given initial and terminal state or any intermediate state in the cell transition trajectory.

Lu Han
Bin Song
Wenxia Zhou
ResearchOpen Access27 Sept 2023
Communications Biology

Volume: 6, P: 1-11
03219A, a new Δ^8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment

Yun Zhang
Xiao Zhou
Jianhua Ju
Research03 Apr 2013
The Journal of Antibiotics

Volume: 66, P: 327-331
Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn’s disease and leprosy

Yonghu Sun
Astrid Irwanto
Jianjun Liu
ResearchOpen Access10 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
A multiomics dataset of paired CT image and plasma cell-free DNA end motif for patients with pulmonary nodules

Mengmeng Zhao
Gang Xue
Yunlang She
ResearchOpen Access01 Apr 2025
Scientific Data

Volume: 12, P: 1-8
Therapeutic siRNA: state of the art

Bo Hu
Liping Zhong
Xing-Jie Liang
ReviewsOpen Access19 Jun 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-25
Colorectal liver metastasis: molecular mechanism and interventional therapy

Hui Zhou
Zhongtao Liu
Yu Wen
ReviewsOpen Access04 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-25
Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study

Likun Hou
Tingting Wang
Xiaojie Pan
Research10 Jan 2022
Modern Pathology

Volume: 35, P: 749-756

Search

Genomic insights into historical improvement of heterotic groups during modern hybrid maize breeding

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling

Author Correction: Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling

Integrated multiomics signatures to optimize the accurate diagnosis of lung cancer

PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer

Engineering a precise adenine base editor with minimal bystander editing

Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens

Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

PC3T: a signature-driven predictor of chemical compounds for cellular transition

03219A, a new Δ^8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment

Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn’s disease and leprosy

A multiomics dataset of paired CT image and plasma cell-free DNA end motif for patients with pulmonary nodules

Therapeutic siRNA: state of the art

Colorectal liver metastasis: molecular mechanism and interventional therapy

Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study

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