Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mechanism, stabilizing XPO1 in a conformation capable of binding to the E3 Cullin–RING E3 ligase 5 substrate receptor ASB8.
- Casey E. Wing
- Ho Yee Joyce Fung
- Yuh Min Chook
