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Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B

Cryo-EM structures of the stabilized prefusion conformation of the glycoprotein B ectodomain—the HSV-1 entry machine—identify a prefusion-specific neutralizing antibody and reveal how prefusion glycoprotein B may evade antibody-mediated neutralization.

Ryan S. Roark
Andrew J. Schaub
Peter D. Kwong
ResearchOpen Access31 Oct 2025
Nature Microbiology

Volume: 10, P: 2966-2980
Author Correction: HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Qingqing Chai
Vladimir Jovasevic
Mojgan H. Naghavi
Amendments and CorrectionsOpen Access05 Jun 2018
Nature Communications

Volume: 9, P: 1
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

A biochemical and structural analysis demonstrates that alterations at the substrate-binding pocket of the main protease of SARS-CoV-2 can allow the virus to develop resistance to nirmatrelvir in two distinct ways.

Yinkai Duan
Hao Zhou
Haitao Yang
Research11 Sept 2023
Nature

Volume: 622, P: 376-382
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-19, but viral resistance to the drug was found to arise readily via multiple pathways in vitro.

Sho Iketani
Hiroshi Mohri
David D. Ho
ResearchOpen Access09 Nov 2022
Nature

Volume: 613, P: 558-564
HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function, results in secretase-dependent Aβ production and neuron degeneration.

Qingqing Chai
Vladimir Jovasevic
Mojgan H. Naghavi
ResearchOpen Access15 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Maria I. Luck
Erick J. Subillaga
Yosef Sabo
ResearchOpen Access08 Apr 2024
Scientific Reports

Volume: 14, P: 1-11

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Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B

Author Correction: HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

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