Hiroyuki Arai and colleagues characterize a new group of epoxy ω-3 fatty acid–derived proinflammatory lipid mediators, an enzyme mediating their biosynthesis and a signaling pathway by which they regulate a threshold of mast cell activation and anaphylaxis, revealing new targets for mast cell–mediated diseases.
- Yuta Shimanaka
- Nozomu Kono
- Hiroyuki Arai
