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Showing 1–2 of 2 results
Advanced filters: Author: Yoshinori Aono Clear advanced filters

  • Sekiya and colleagues identify that, in response to reductive metabolism, CtBP2 is secreted via exosomes and regulates metabolism in recipient cells via CYB5R3 and AMPK. Exosomal CtBP2 administration extends lifespan and healthspan in aged mice, and serum levels of CtBP2 decline with age in humans.

    • Motohiro Sekiya
    • Kenta Kainoh
    • Hitoshi Shimano
    Research
    Nature Aging
    Volume: 5, P: 2197-2214

  • Acquired resistance to anti-angiogenic drugs, including bevacizumab, may occur in cancer patients. In this study the authors identify in the tumour microenvironment, fibrocyte-like cells derived from the bone marrow that mediate the resistance to bevacizumab through the production of FGF2.

    • Atsushi Mitsuhashi
    • Hisatsugu Goto
    • Yasuhiko Nishioka
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15