The impact of intermittent hypoxia (1 min at 5% O2 and 5 min at 20% O2, 8 h/day) for 4 weeks (IH4W) in Ogt-Tg mice. Augmented O-GlcNAcylation may aggravate IH4W-induced right ventricular dysfunction and remodeling by promoting hypertrophy, mitophagy, and fibrosis via GSK-3β inactivation, increased p-Drp-1/MFN2 ratio, and Smad2 activation, respectively.
- Shunichi Yokoe
- Tetsuya Hayashi
- Michio Asahi
