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Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

Using two-photon imaging of neuronal activity in mouse motor cortex during the acquisition of a self-initiated lever-pull task, Masamizu and colleagues demonstrate that learning is accompanied by a reorganization of ensemble activity in layer 5a. This reorganization correlates with an increase in ensemble prediction of task accuracy. The authors also find that no such changes take place in layer 2/3.

Yoshito Masamizu
Yasuhiro R Tanaka
Masanori Matsuzaki
Research01 Jun 2014
Nature Neuroscience

Volume: 17, P: 987-994
Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks

Marmosets are an important model organism in neuroscience but there has only been limited success in training them on behavioral tasks. Here the authors report their ability to train marmosets in various motor tasks and simultaneously image neural dynamics in motor cortex with 2-photon imaging.

Teppei Ebina
Yoshito Masamizu
Masanori Matsuzaki
ResearchOpen Access14 May 2018
Nature Communications

Volume: 9, P: 1-16
Instability of Hes7 protein is crucial for the somite segmentation clock

Hiromi Hirata
Yasumasa Bessho
Ryoichiro Kageyama
Research30 May 2004
Nature Genetics

Volume: 36, P: 750-754
Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning

Motor cortex is critical for sensorimotor learning. Here the authors show that dynamic directional motor tuning in premotor cortex, but not primary motor cortex, is related to improvement in performance of the newly learned movement.

Teppei Ebina
Akitaka Sasagawa
Masanori Matsuzaki
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-21
ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex

To express a biosensor in primate cortex, multiple injections of virus carrying the sensor gene are necessary. Here, the authors develop an automated robotic system for multiple, safe injections.

Shinnosuke Nomura
Shin-Ichiro Terada
Masanori Matsuzaki
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-23
Change detection in the primate auditory cortex through feedback of prediction error signals

The brain can quickly detect sounds that are not predicted. Here, the authors show that propagation of prediction error signals from higher-order auditory cortex to primary auditory cortex is critical for the change detection in the non-human primates.

Keitaro Obara
Teppei Ebina
Masanori Matsuzaki
ResearchOpen Access13 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning

The mammalian brain is able to rapidly adapt to environmental changes, but it is unclear how this occurs at the level of the single neuron. Hira et al.use two-photon calcium imaging of neurons in the mouse motor cortex after a lever-pull task to demonstrate rapid operant conditioning of single neurons.

Riichiro Hira
Fuki Ohkubo
Masanori Matsuzaki
Research24 Nov 2014
Nature Communications

Volume: 5, P: 1-12

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Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks

Instability of Hes7 protein is crucial for the somite segmentation clock

Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning

ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex

Change detection in the primate auditory cortex through feedback of prediction error signals

Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning

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