Shcherbakov et al. investigate the consequences of ribosome mistranslation in human cells, by expressing a mutant version of the small ribosomal subunit protein RPS2. They observe activation of protein quality control pathways, but also increased mitochondrial biogenesis and silencing of the unfolded protein response in the endoplasmic reticulum.
- Dmitri Shcherbakov
- Youjin Teo
- Erik C. Böttger
