The synthesis of β-amino acid molecules via tandem radical 1,2-N-shift/cross-coupling of α-amino acid scaffolds represents an attractive and powerful tool. Herein, the authors report the cross-electrophile C(sp2)-C(sp3) coupling of β-bromo α-amino acid esters with aryl bromides via a π-system-independent 1,2-N-shift, which allows access to α-arylated β-amino acid motifs with high efficiency and regioselectivity.
- Zicheng Liao
- Zijun Li
- Shi Tang
