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Showing 1–4 of 4 results
Advanced filters: Author: Young Cheun Clear advanced filters

  • The spatial context of epitranscriptomic features in the tumour microenvironment remains poorly understood. Here, a method for transcriptomic and epitranscriptomic analysis of immunofluorescence-stained tissue, Select-seq, is applied to stem cell-like microniches in triple negative breast cancer.

    • Amos C. Lee
    • Yongju Lee
    • Sunghoon Kwon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine (oxoA) are generated upon oxidative damage to DNA, but the biological effects of oxoA are not well known. Here, the authors report that only oxoA forms DNA interstrand crosslinks (ICLs) upon secondary oxidation and that these ICLs can be induced by reactive halogen species, one-electron oxidants and the myeloperoxidase/H2O2/Cl- system.

    • Aaron L. Rozelle
    • Young Cheun
    • Seongmin Lee
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The International Glaucoma Genetics Consortium reports a genome-wide association study meta-analysis of optic disc parameters relevant to primary open-angle glaucoma. They identify two novel variants in PPP1R36-PLEKHG3 and SERPINE3 by multi-trait analysis in European-ancestry cohorts that were replicated in independent Asian cohorts.

    • Pieter W. M. Bonnemaijer
    • Elisabeth M. van Leeuwen
    • Cornelia M. van Duijn
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-12