The interplay between tau and amyloid-β (Aβ) in the development of Alzheimer’s disease is not fully understood. It has now been shown that tau’s microtubule-binding repeat regions, which contain a combination of hydrophobic and hydrophilic sections, interact with Aβ to form hetero-assemblies, which can modify Aβ amyloidogenesis and alleviate Aβ-induced cytotoxicity.
- Mingeun Kim
- Yuxi Lin
- Mi Hee Lim
