Nature Search

Alteration of metabolic activity regulates mitochondrial temperature in diagnosis in HepG2 hepatocellular carcinoma cells

Ola A. Gaser
Mohamed A. Nasr
Nagwa El-Badri
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
Myoseverin, a microtubule-binding molecule with novel cellular effects

Gustavo R. Rosania
Young-Tae Chang
Peter G. Schultz
Research01 Mar 2000
Nature Biotechnology

Volume: 18, P: 304-308
Author Correction: Distinct chemical environments in biomolecular condensates

Henry R. Kilgore
Peter G. Mikhael
Richard A. Young
Amendments and Corrections25 Oct 2023
Nature Chemical Biology

Volume: 19, P: 1561
A Molecular Fluorescent Probe for Targeted Visualization of Temperature at the Endoplasmic Reticulum

Satoshi Arai
Sung-Chan Lee
Young Tae Chang
ResearchOpen Access21 Oct 2014
Scientific Reports

Volume: 4, P: 1-6
ENOblock inhibits the pathology of diet-induced obesity

Haaglim Cho
Ji-Hyung Lee
Darren R. Williams
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-24
Super-photostable organic dye for long-term live-cell single-protein imaging

Phoenix Fluor 555 (PF555) is a bright dye with an exceptional, order-of-magnitude longer photobleaching lifetime than conventional organic dyes that enables extended live-cell single-molecule imaging without anti-photobleaching additives.

Do-Hyeon Kim
Hong Minh Triet
Sung Ho Ryu
Research15 Jan 2025
Nature Methods

Volume: 22, P: 550-558
Small-molecule switch for zebrafish gene expression

The zebrafish is a highly promising model system for vertebrate genetics study, but the temporal control of gene expression has remained underdeveloped. A new chemical genetic system using a small-molecule switch for protein synthesis promises to increase the usefulness of the zebrafish as a vertebrate model system.

Young-Tae Chang
News & Views01 Mar 2007
Nature Chemical Biology

Volume: 3, P: 135-136
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

Jaeki Min
Yun Kyung Kim
Young-Tae Chang
Research19 Nov 2006
Nature Chemical Biology

Volume: 3, P: 55-59
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

Mitchell J. Machiela
Weiyin Zhou
Stephen J. Chanock
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target

Studying the specific roles of macrophage subsets has been hampered by a lack of subset-specific probes. Here the authors report an M1 selective fluorescent probe named CDr17, and demonstrate the suitability of this probe for tracking M1 macrophages in vivo.

Heewon Cho
Haw-Young Kwon
Young-Tae Chang
ResearchOpen Access10 Oct 2022
Nature Communications

Volume: 13, P: 1-8
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously reported associations.

Qing Lan
Chao A Hsiung
Nathaniel Rothman
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1330-1335
Distinct chemical environments in biomolecular condensates

Condensates have been proposed to create a distinct chemical solvating environment. In vitro condensate screens suggest that condensate chemical environments influence the intracellular distribution of small molecules.

Henry R. Kilgore
Peter G. Mikhael
Richard A. Young
Research28 Sept 2023
Nature Chemical Biology

Volume: 20, P: 291-301
Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to image atherosclerosis in mice.

Sung-Jin Park
Beomsue Kim
Young-Tae Chang
ResearchOpen Access07 Mar 2019
Nature Communications

Volume: 10, P: 1-7
Development of background-free tame fluorescent probes for intracellular live cell imaging

The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

Samira Husen Alamudi
Rudrakanta Satapathy
Young-Tae Chang
ResearchOpen Access20 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Visualizing Alzheimer’s Disease Mouse Brain with Multispectral Optoacoustic Tomography using a Fluorescent probe, CDnir7

Sung-Jin Park
Chris Jun Hui Ho
Young-Tae Chang
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe

Liyun Zhang
Jun Cheng Er
Young-Tae Chang
ResearchOpen Access20 Jan 2014
Scientific Reports

Volume: 4, P: 1-6
Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1

Nam-Young Kang
Seong-Wook Yun
Young-Tae Chang
Protocols30 Jun 2011
Nature Protocols

Volume: 6, P: 1044-1052
Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models

Sun Young Kim
Jinhyeon Kim
Seung-Jae Myung
ResearchOpen Access06 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
A protocol for preparing, characterizing and using three RNA-specific, live cell imaging probes: E36, E144 and F22

Qian Li
Young-Tae Chang
Protocols25 Jan 2007
Nature Protocols

Volume: 1, P: 2922-2932
Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

Rókus Kriszt
Satoshi Arai
Michael Raghunath
ResearchOpen Access03 May 2017
Scientific Reports

Volume: 7, P: 1-14
Actively Targeted In Vivo Multiplex Detection of Intrinsic Cancer Biomarkers Using Biocompatible SERS Nanotags

U. S. Dinish
Ghayathri Balasundaram
Malini Olivo
ResearchOpen Access12 Feb 2014
Scientific Reports

Volume: 4, P: 1-7
Make Caffeine Visible: a Fluorescent Caffeine “Traffic Light” Detector

Wang Xu
Tae-Hyeong Kim
Young-Tae Chang
ResearchOpen Access23 Jul 2013
Scientific Reports

Volume: 3, P: 1-7
Identification of disulfide cross-linked tau dimer responsible for tau propagation

Dohee Kim
Sungsu Lim
Yun Kyung Kim
ResearchOpen Access15 Oct 2015
Scientific Reports

Volume: 5, P: 1-10

Search

Alteration of metabolic activity regulates mitochondrial temperature in diagnosis in HepG2 hepatocellular carcinoma cells

Myoseverin, a microtubule-binding molecule with novel cellular effects

Author Correction: Distinct chemical environments in biomolecular condensates

A Molecular Fluorescent Probe for Targeted Visualization of Temperature at the Endoplasmic Reticulum

ENOblock inhibits the pathology of diet-induced obesity

Super-photostable organic dye for long-term live-cell single-protein imaging

Small-molecule switch for zebrafish gene expression

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Distinct chemical environments in biomolecular condensates

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Development of background-free tame fluorescent probes for intracellular live cell imaging

Visualizing Alzheimer’s Disease Mouse Brain with Multispectral Optoacoustic Tomography using a Fluorescent probe, CDnir7

Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe

Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1

Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models

A protocol for preparing, characterizing and using three RNA-specific, live cell imaging probes: E36, E144 and F22

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

Actively Targeted In Vivo Multiplex Detection of Intrinsic Cancer Biomarkers Using Biocompatible SERS Nanotags

Make Caffeine Visible: a Fluorescent Caffeine “Traffic Light” Detector

Identification of disulfide cross-linked tau dimer responsible for tau propagation

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