Nature Search

Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation

Lipid nanoparticles (LNPs) are a versatile class of clinically approved drug delivery vehicles, particularly for nucleic acid cargoes, but they often suffer from instability issues. Here, the authors report that the room temperature stability of small interfering RNA LNPs formulated with unsaturated ionizable lipids can be improved by inclusion of mildly acidic, antioxidant-containing buffers.

Daniel A. Estabrook
Lihua Huang
Tingting Wang
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Hierarchically self-assembled hexagonal honeycomb and kagome superlattices of binary 1D colloids

Binary mixtures of 1D particles are rarely observed to cooperatively self-assemble into binary superlattices, as the particle types separate into phases. Here, the authors design a system that avoids phase separation, obtaining binary superlattices with different symmetries by simply tuning the particle diameter and mixture composition.

Sung-Hwan Lim
Taehoon Lee
Sung-Min Choi
ResearchOpen Access25 Aug 2017
Nature Communications

Volume: 8, P: 1-9
Ultra-wide-field imaging Mueller matrix spectroscopic ellipsometry for semiconductor metrology

An ultra-wide-field imaging Mueller matrix spectroscopic ellipsometry system with a 20 mm × 20 mm field of view was developed for semiconductor metrology. Over 10 million spectra were analyzed with machine learning, allowing wafer-scale variations to be identified and yield gains demonstrated.

Juntaek Oh
Jaehyeon Son
Taeyong Jo
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Regulation of systemic energy homeostasis by serotonin in adipose tissues

The neurotransmitter serotonin has both central and peripheral effects. Here, the authors show that adipocyte-derived serotonin regulates organismal energy homeostasis in mice by acting on adipocyte serotonin receptors on fat cells, which regulates lipolysis and thermogenesis in white and brown fat tissue.

Chang-Myung Oh
Jun Namkung
Hail Kim
ResearchOpen Access13 Apr 2015
Nature Communications

Volume: 6, P: 1-12
Transparent and attachable ionic communicators based on self-cleanable triboelectric nanogenerators

Flexible, transparent wearable electronics harvesting energy from human motion are nearing reality, but stable adhesion while staying clean remains a problem. Here the authors solve both issues with a functionalized organic polymer/hydrogel-based device capable of wireless communication via finger gestures.

Younghoon Lee
Seung Hee Cha
Jeong-Yun Sun
ResearchOpen Access04 May 2018
Nature Communications

Volume: 9, P: 1-8
Dynamic multimodal holograms of conjugated organogels via dithering mask lithography

Periodic patterns with varying cross-linking densities are realized in conjugated polydiacetylene films, creating multiple holographic images—all dynamically responsive to exposure to various solvents—simultaneously in the same polymeric structures.

Jongwon Oh
Dahye Baek
Jiseok Lee
Research04 Jan 2021
Nature Materials

Volume: 20, P: 385-394
One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays

High-throughput screening allows for the rapid assessment of biochemical compounds and processes, but with increasing scale comes increasing costs. Here, the authors use an array of lithographically encoded hydrogel microparticles as a more accessible screening technique.

Su Eun Chung
Jiyun Kim
Sunghoon Kwon
Research17 Mar 2014
Nature Communications

Volume: 5, P: 1-12
Deep reinforcement learning-designed radiofrequency waveform in MRI

Radiofrequency pulses of different shapes can increase the efficiency of applications such as broadcasting or medical imaging, but finding the optimal shape for a specific use can be computationally costly. Shin and colleagues present a new method based on deep reinforcement learning to design radiofrequency pulses for use in MRI, which is demonstrated to cover different types of optimization goals for each application.

Dongmyung Shin
Younghoon Kim
Jongho Lee
Research16 Nov 2021
Nature Machine Intelligence

Volume: 3, P: 985-994
Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor

Mi Ri Park
Sangdon Ryu
Younghoon Kim
ResearchOpen Access10 May 2018
Scientific Reports

Volume: 8, P: 1-10
Challenges and opportunities in computational studies for lipid nanoparticle development

Younghoon Oh
Sean K. Bedingfield
Scott P. Brown
ReviewsOpen Access01 Sept 2025
npj Drug Discovery

Volume: 2, P: 1-7
Artificial intelligence algorithm for detecting myocardial infarction using six-lead electrocardiography

Younghoon Cho
Joon-myoung Kwon
Byung-Hee Oh
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Multi-layering of a nanopatterned TiO₂ layer for highly efficient solid-state solar cells

A facile process to prepare multi-layered nanopatterned photoanodes (MNPs) is presented with well-arrayed mesoporous inorganic oxide layers. The MNPs were prepared by multiple stacking of nanopatterned TiO₂ layers using a sacrificial polystyrene-thin film layer, which not only guided the stacking TiO₂ layer but also was removed completely by calcination without generating cracks. The MNPs were applied to solid-state solar cells, to exhibit an enhancement of 73% and a 65% in J_sc and power conversion efficiency (PCE), respectively.

Jongbeom Na
Younghoon Kim
Eunkyoung Kim
ResearchOpen Access25 Sept 2015
NPG Asia Materials

Volume: 7, P: e217
p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy

Hyeon Jeong Oh
Jeong Mo Bae
Gyeong Hoon Kang
ResearchOpen Access21 Mar 2019
British Journal of Cancer

Volume: 120, P: 797-805
SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma

SLUG is expressed in the myoepithelial cells of normal salivary glands and is highly upregulated in the neoplastic myoepithelial cells and stromal cells of pleomorphic adenoma (PA). SLUG is less likely to be affected by PLAG1. SLUG is involved in the regulation of epithelial-mesenchymal transition (EMT) marker expression in primary cultured PA cells, indicating that SLUG might be a key transcription factor controlling EMT in PA.

Hyesung Kim
Seung Bum Lee
Bogun Jang
Research10 Feb 2022
Laboratory Investigation

Volume: 102, P: 631-640
Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer

Stephanie Rockfield
Younghoon Kee
Meera Nanjundan
ResearchOpen Access21 Aug 2019
Oncogenesis

Volume: 8, P: 1-21
Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis

Fusarium venenatum is a potential protein source in Caenorhabditis elegans and mice that exhibits anti-obesity properties by improving lipid profiles and reducing fat accumulation.

Daniel Junpyo Lee
An Na Kang
Younghoon Kim
ResearchOpen Access26 Jan 2024
Communications Biology

Volume: 7, P: 1-14
Correction: Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Sun Joo Lee
Ji Yun Jeong
In-Kyu Lee
Amendments and CorrectionsOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1
Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation

Byong-Keol Min
Chang Joo Oh
In-Kyu Lee
ResearchOpen Access30 Sept 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-12
Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Sun Joo Lee
Ji Yun Jeong
In-Kyu Lee
ResearchOpen Access12 Nov 2015
Scientific Reports

Volume: 5, P: 1-17
Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota

Mi Ri Park
Minhye Shin
Sangnam Oh
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Jae-Ho Lee
Younghoon Go
Seung-Soon Im
ResearchOpen Access03 Feb 2020
Experimental & Molecular Medicine

Volume: 52, P: 238-252
Correction: Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Jae-Ho Lee
Younghoon Go
Seung-Soon Im
Amendments and CorrectionsOpen Access15 Jun 2020
Experimental & Molecular Medicine

Volume: 52, P: 988

Search

Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation

Hierarchically self-assembled hexagonal honeycomb and kagome superlattices of binary 1D colloids

Ultra-wide-field imaging Mueller matrix spectroscopic ellipsometry for semiconductor metrology

Regulation of systemic energy homeostasis by serotonin in adipose tissues

Transparent and attachable ionic communicators based on self-cleanable triboelectric nanogenerators

Dynamic multimodal holograms of conjugated organogels via dithering mask lithography

One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays

Deep reinforcement learning-designed radiofrequency waveform in MRI

Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor

Challenges and opportunities in computational studies for lipid nanoparticle development

Artificial intelligence algorithm for detecting myocardial infarction using six-lead electrocardiography

Multi-layering of a nanopatterned TiO₂ layer for highly efficient solid-state solar cells

p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy

SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma

Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer

Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis

Correction: Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota

Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Correction: Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

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