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Showing 1–1 of 1 results
Advanced filters: Author: Younji Sim Clear advanced filters

  • HMGCR is upregulated by E2F1, driving ferroptosis resistance by reducing oxidative damage triggered by T cell-based therapy. Notably, targeting HMGCR restores ferroptosis sensitivity in immune-refractory tumors, enhancing response to PD-1 blockade as well as adoptive T cell transfer therapy.

    • Sung Wook Son
    • Hyo-Jung Lee
    • Kwon-Ho Song
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18