Understanding the downstream signal transduction process of the CXCL12–CXCR4–Gαi tricomplex could prove useful in the development of anticancer and antimetastatic drugs. Here the authors propose an internal water channel formation model for CXCL12-bound CXCR4 in complex with Gαi-protein upon activation for downstream signaling.
- Chun-Chun Chang
- Je-Wen Liou
- Hao-Jen Hsu
