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Advanced filters: Author: Yu-Ming Chuang Clear advanced filters

Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

The compassionate use of l-asparaginase in patients suffering from nasopharyngeal carcinoma substantially strengthens the efficacy of immune-checkpoint blockade therapy by enhancing T cell fitness.

Hsuan-Chia Chang
Chung-Ying Tsai
Huang-Yu Yang
ResearchOpen Access05 Mar 2025
Nature Metabolism

Volume: 7, P: 918-927
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B

Glucocorticoids show promise for the treatment of ovarian cancer. Here the authors show that glucocorticoids transcriptionally induce the tumour suppressor miR-708, which is downregulated in ovarian cancer, especially in late stages and metastatic tumours.

Kai-Ti Lin
Yu-Ming Yeh
Lu-Hai Wang
ResearchOpen Access08 Jan 2015
Nature Communications

Volume: 6, P: 1-13
Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics

Mita T. M. T. Tran
Fu-Chen Kuo
Michael W. Y. Chan
ResearchOpen Access06 May 2023
Scientific Reports

Volume: 13, P: 1-10