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Advanced filters: Author: Yuan-Hsin Shih Clear advanced filters

REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes

Wu et al. demonstrate that REM transcription factors and GDE1 guide RNA polymerase IV to specific genomic loci, establishing a DNA sequence-dependent mechanism for siRNA biogenesis and DNA methylation patterning.

Zhongshou Wu
Yan Xue
Steven E. Jacobsen
ResearchOpen Access27 Jun 2025
Nature Cell Biology

Volume: 27, P: 1136-1147
Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

TRB proteins have been shown to recruit PRC2 for H3K27me3 deposition. This work shows that TRBs also recruit JMJ14 to remove H3K4me3, demonstrating that TRBs silence the target genes via a combinatorial histone modification mechanism.

Ming Wang
Zhenhui Zhong
Steven E. Jacobsen
ResearchOpen Access28 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2

Arabidopsis H3K9 methyltransferases directly interact with ASYMMETRIC LEAVES1 (AS1) and AS2 to repress KNOTTED-LIKE FROM ARABIDOPSIS THALIANA 1 (KNAT1) and KNAT2 in leaf development.

Fu-Yu Hung
Yun-Ru Feng
Keqiang Wu
ResearchOpen Access24 Feb 2023
Communications Biology

Volume: 6, P: 1-13