Aberrant activation of Wnt/β-catenin signaling contributes to colorectal cancer (CRC) pathogenesis. Here the authors find that the cytoplasmic distribution of TRIM24 E3 ubiquitin ligase triggers ubiquitination and degradation of von Hippel-Lindau, resulting in the accumulation of β-catenin protein in CRC cells.
- Ya Wang
- Yuanbing Yao
- Kai Fu
