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Showing 1–6 of 6 results
Advanced filters: Author: Yuanchang Zhao Clear advanced filters

  • Cryo-electron microscopy and biochemical reconstitution analysis reveals that Nde1 enhances Lis1 binding to autoinhibited dynein, promoting formation of a Phi-like–Lis1 intermediate during dynein activation.

    • Jun Yang
    • Yuanchang Zhao
    • Kai Zhang
    Research
    Nature Chemical Biology
    Volume: 22, P: 274-283

  • The spindle assembly factor HURP and the kinesin motor Kif18A are known to regulate mitotic spindle dynamics. Here, the authors show that HURP concentration on kinetochore-fibers modulates the landing and motility of Kif18A, providing a mechanism for microtubule length control.

    • Juan M. Perez-Bertoldi
    • Yuanchang Zhao
    • Eva Nogales
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Autophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

    • Minghao Chen
    • Thanh N. Nguyen
    • James H. Hurley
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1596-1605

  • Lis1 and Nde1/Ndel1 mediate the initiation of dynein-driven transport, but the mechanism remains unclear. Here, the authors reveal that Nde1 recruits Lis1 to autoinhibited dynein and promotes Lis1-mediated assembly of active dynein transport machinery.

    • Yuanchang Zhao
    • Sena Oten
    • Ahmet Yildiz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Lis1 binding to the AAA+ ring of dynein increases the microtubule affinity and slows dynein motility. Lis1 binding to the stalk of dynein restricts the sliding of the coiled coils and slows detachment from microtubules under load.

    • Emre Kusakci
    • Zaw Min Htet
    • Ahmet Yildiz
    Research
    Nature Chemical Biology
    Volume: 20, P: 521-529