Nature Search

Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation

Mao et al. reported ribosomal frameshifting events shortly after start codon selection, which is influenced by the sequence context and controlled by initiation factor eIF5B. This translational ‘noise’ is increased in response to nutrient starvation.

Yuanhui Mao
Longfei Jia
Shu-Bing Qian
Research13 Nov 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1816-1825
Decoding mRNA translatability and stability from the 5′ UTR

Massively parallel reporter assays from a synthetic mRNA library identify sequence features of 5′ UTRs that control mRNA translatability and reveal ribosome-dependent and ribosome-independent mRNA-surveillance pathways.

Longfei Jia
Yuanhui Mao
Shu-Bing Qian
Research27 Jul 2020
Nature Structural & Molecular Biology

Volume: 27, P: 814-821
Deep learning prediction of ribosome profiling with Translatomer reveals translational regulation and interprets disease variants

A transformer-based approach called Translatomer is presented, which models cell-type-specific translation from messenger RNA expression and gene sequence, bridging the gap between messenger RNA and protein levels as well as providing a mechanistic insight into the genetic regulation of translation.

Jialin He
Lei Xiong
Xushen Xiong
Research23 Oct 2024
Nature Machine Intelligence

Volume: 6, P: 1314-1329
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress

Nutrient stress induces ATF4 expression via translation reinitiation, which involves eIF3 retainment on the elongating ribosome. This translational reprogramming is mediated by stress-induced removal of the O-GlcNAc modification from eIF3a.

Xin Erica Shu
Yuanhui Mao
Shu-Bing Qian
Research09 Dec 2021
Nature Chemical Biology

Volume: 18, P: 134-141
Bi-directional ribosome scanning controls the stringency of start codon selection

Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.

Yifei Gu
Yuanhui Mao
Shu-Bing Qian
ResearchOpen Access15 Nov 2021
Nature Communications

Volume: 12, P: 1-12
m⁶A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Several functions have been proposed for m⁶A in RNA metabolism, yet little is known regarding the specific functions of individual m⁶A readers. Here, the authors observe that the m⁶A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by resolving secondary structures.

Yuanhui Mao
Leiming Dong
Shu-Bing Qian
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Programmable RNA N⁶-methyladenosine editing by CRISPR-Cas9 conjugates

Fusion of Cas9 with m6A writers METTL3 and METTL14 or eraser ALKBH5 enables site-specific writing or erasing of RNA m6A modifications in mammalian cells and investigation of individual m6A modification-mediated function.

Xiao-Min Liu
Jun Zhou
Shu-Bing Qian
Research05 Aug 2019
Nature Chemical Biology

Volume: 15, P: 865-871
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer

Yuan Luo
Mengqi Sun
Tingbo Liang
ResearchOpen Access06 Oct 2025
Cell Death & Disease

Volume: 16, P: 1-16
Ribosome-guided piRNA production

The ribosome decodes messenger RNAs and constructs proteins based on the genetic blueprint. Ribosomes also associate with non-coding RNAs, such as PIWI-interacting RNA (piRNA) precursors, during the meiotic pachytene stage. Intriguingly, the ribosome mediates pachytene piRNA biogenesis by guiding endonucleolytic cleavage of piRNA precursors.

Yuanhui Mao
Shu-Bing Qian
News & Views03 Feb 2020
Nature Cell Biology

Volume: 22, P: 141-142
SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

Bisi Miao
Ling Ge
Fei Lan
ResearchOpen Access05 Aug 2024
Cell Research

Volume: 34, P: 648-660
Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine

Kevin M. Mazor
Leiming Dong
Martha H. Stipanuk
ResearchOpen Access24 May 2018
Scientific Reports

Volume: 8, P: 1-13

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