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Showing 1–3 of 3 results
Advanced filters: Author: Yuanwei Gou Clear advanced filters

  • Peroxisomes have emerged as ideal compartments for hosting heterologous biochemical reactions. A study establishes a modular chauffeur strategy for functional expression and trafficking of multi-spanning transporters and integral membrane enzymes into the yeast peroxisomal membrane for metabolic engineering.

    • Yuanwei Gou
    • Xiaojing Jiang
    • Jiazhang Lian
    News & Views
    Nature Chemical Biology
    Volume: 21, P: 1478-1480

  • Sanguinarine is a plant-derived benzylisoquinoline alkaloid that exhibits diverse pharmacological activities. Here, the authors report the complete biosynthesis of sanguinarine and halogenated derivatives using engineered yeast strains through a temperature-responsive dynamic control strategy.

    • Yuanwei Gou
    • Dongfang Li
    • Jiazhang Lian
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Liu et al. optimize vindoline biosynthesis in yeast from tabersonine by altering the copy numbers of pathway genes, pairing CYPs with CPRs, engineering the microenvironment for functional expression of CYPs, enhancing cofactor supplies, and optimizing fermentation conditions. By doing so, the authors increased the production of vindoline to a final titer as high as ∼16.5 mg/L.

    • Tengfei Liu
    • Ying Huang
    • Jiazhang Lian
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9