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Showing 1–3 of 3 results
Advanced filters: Author: Yuefan Bai Clear advanced filters

  • This study discovers that tRNA directly binds and regulates the membrane protein FKS1, a β-1,3-glucan synthase essential for fungal cell wall formation. Cryo-EM and biochemical analyses show how tRNA and GSR1 control FKS1 activity and fungal growth.

    • Jialu Li
    • Jian Li
    • Xiang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • MANF is a secreted ER stress-inducible protein that protects neurons, pancreatic β cells and cardiomyocytes from cell death under oxidative stress, hypoxic or ischemic conditions. Here the authors show that MANF confers cytoprotection through direct binding to sulfatide followed by cellular uptake in both C. elegans and mammalian cells.

    • Meirong Bai
    • Roman Vozdek
    • Dengke K. Ma
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11