p53-mediated replicative senescence is associated with downregulation of the inhibitory p53 isoform Δ133p42α. Horikawa et al.show that this downregulation is a result of specific targeting of Δ133p42α for autophagic degradation by the E3 ubiquitin ligase STUB1.
- Izumi Horikawa
- Kaori Fujita
- Curtis C. Harris