For high-performance boron neutron capture therapy , core-shell-type biodegradable nanoparticle-containing boron cluster is designed in order to improve accumulation tendency to tumor. Copolymerization of styrene carrying carborane with poly(ethylene glycol)-block-poly(lactide) (PEG-b-PLA-MA), possessing a methacryloyl group at the PLA end is performed. The accumulation of the polymerized micelles in tumor is much higher than that of the non-polymerized micelles because of the enhancement of the stability of the micelles. Thermal neutron irradiation exhibits significant suppression of tumor growth in the mice treated with the polymerized micelles.
- Shogo Sumitani
- Yukio Nagasaki
