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Showing 1–2 of 2 results
Advanced filters: Author: Yuliia Holota Clear advanced filters
  • The phenyl ring is a basic structural element in chemistry. Here, the authors show the design, synthesis, and validation of 2-oxabicyclo[2.2.2]octane as a new saturated bioisostere with improved physicochemical properties

    • Vadym V. Levterov
    • Yaroslav Panasiuk
    • Pavel K. Mykhailiuk
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10
  • The ortho-substituted phenyl ring is a basic structural element in chemistry. Now, 2-oxabicyclo[2.1.1]hexanes have been developed as saturated bioisosteres of the ortho-substituted phenyl ring with improved physicochemical properties. Replacement of the phenyl ring with 2-oxabicyclo[2.1.1]hexanes in marketed agrochemicals fluxapyroxad and boscalid improved water solubility, reduced lipophilicity and retained bioactivity.

    • Aleksandr Denisenko
    • Pavel Garbuz
    • Pavel K. Mykhailiuk
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1155-1163