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Showing 1–3 of 3 results
Advanced filters: Author: Yuliya Politanska Clear advanced filters

  • Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

    • Rogan A. Grant
    • Luisa Morales-Nebreda
    • Ziyou Ren
    Research
    Nature
    Volume: 590, P: 635-641

  • The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

    • Cameron J. Glasscock
    • Robert J. Pecoraro
    • David Baker
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 2252-2261

  • Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

    • Nikolay S. Markov
    • Ziyou Ren
    • Brian White
    Research
    Nature Immunology
    Volume: 25, P: 1607-1622