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Showing 1–3 of 3 results
Advanced filters: Author: Yuma Ishigami Clear advanced filters

  • Two small-molecule drugs, risdiplam and branaplam, have been developed for treating spinal muscular atrophy. Here the authors develop quantitative modeling methods for the sequence-specific and concentration-dependent effects of these and other splice-modifying drugs.

    • Yuma Ishigami
    • Mandy S. Wong
    • Justin B. Kinney
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.

    • Yuma Ishigami
    • Takayuki Ohira
    • Tsutomu Suzuki
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Mitochondrial tRNA modifications are important for tRNA stability and accurate decoding. By employing RNA mass spectrometry and deep sequencing, here the authors provide a comprehensive analysis of post-transcriptional modifications of 22 species of human mitochondrial tRNAs.

    • Takeo Suzuki
    • Yuka Yashiro
    • Tsutomu Suzuki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15