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Showing 1–4 of 4 results
Advanced filters: Author: Yunchen Jiang Clear advanced filters

  • Despite the promising potential of the perfluoro-tert-butyl (PFtB) group in diverse fields, incorporating PFtB into organic molecules remains challenging. Here, the authors describe a stable and scalable reagent for radical-type perfluoro-tert-butylation, which is synthesized in large scale from commercial perfluoro-tert-butanol and a designed benzothiazole hypervalent iodonium salt.

    • Ruitong Zhang
    • Shengqi Zhou
    • Chao Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • The isoperfluoropropyl group (i-C3F7) is an analogue of the trifluoromethyl group (CF3) featuring a stronger electron-withdrawing effect and more steric hindrance, giving it a unique role in synthetic chemistry, however, direct isoperfluoropropylation remains challenging. Here, the authors develop a highly reactive electrophilic hypervalent-iodine based i-C3F7 reagent and demonstrate its use for the efficient isoperfluoropropylation of aromatic C–H bonds.

    • Yaxing Wu
    • Yunchen Jiang
    • Chao Chen
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • The gem-difluoroethylene moiety is considered as a valuable building block in organic synthesis, but methods to introduce it into small molecules are generally limited to specific substrates. Here, the authors demonstrate that a gem-difluorovinyl iodonium salt enables the direct difluoroethylation reactions of a diverse range of N- and O-nucleophiles.

    • Chenxin Ge
    • Bin Wang
    • Chao Chen
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-10