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Cell Death Discovery (1)

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Showing 1–4 of 4 results

Advanced filters: Author: Yunge Yang Clear advanced filters

Transcription regulation of African swine fever virus: dual role of M1249L

African swine fever virus (ASFV) is a contagious DNA virus causing lethal disease in swine. This study reveals structures of ASFV RNA polymerase bound to protein M1249L, showing its vital roles in regulating early transcription and packaging.

Dongming Zhao
Nan Wang
Xiangxi Wang
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Structural insights into the DNA topoisomerase II of the African swine fever virus

African swine fever virus is the sole mammalian-infecting virus encoding a type II topoisomerases (pP1192R). The authors present pP1192R structures in different states, illustrating the enzymatic mechanisms of viral type II topoisomerases.

Jingyuan Cong
Yuhui Xin
Yutao Chen
ResearchOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-12
Structural and functional insights into the T-even type bacteriophage topoisomerase II

Here the authors determine multiple conformational structures of T4 and T6 bacteriophage topoisomerase IIs when breaking G-segment DNA, identifying a unique insertion in the TOPRIM domain of the T4 topoisomerase II, and a difference in the catalytic centers of the dimers.

Yuhui Xin
Runqi Xian
Yutao Chen
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer

Luomeng Qian
Xiaoshan Yang
Biliang Chen
ResearchOpen Access18 May 2021
Cell Death Discovery

Volume: 7, P: 1-11