The diffusion resistance of reaction intermediates is a major rate-limiting factor in chemoenzymatic cascades and can be reduced by integrating metal catalytic modules and enzymes in a single catalyst due to the proximity effect. Here, the authors assemble enzymatic and dual metal-single-atom photocatalytic modules in a single active pocket for “one binding two reactions” catalysis, which can eliminate the diffusion resistance of reaction intermediates, and catalyze transfer hydrogenation and oxidation reactions under visible light.
- Yunkai Fan
- Jia Hu
- Xiaoyang Li
