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Showing 1–8 of 8 results
Advanced filters: Author: Yunsun Nam Clear advanced filters

  • Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.

    • Alexander C. Partin
    • Tri D. Ngo
    • Yunsun Nam
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Su et al. report that while METTL16 acts as an m6A writer in the nucleus, it exerts an m6A-independent function in the cytosol, where it facilitates translation through direct interactions with ribosomal RNAs and eukaryotic initiation factors 3a and -b.

    • Rui Su
    • Lei Dong
    • Jianjun Chen
    Research
    Nature Cell Biology
    Volume: 24, P: 205-216

  • This is one of two papers that report the long-awaited structure of the SecA–SecY complex from bacteria. The structure reveals major conformational changes between both partners and suggests that SecA uses a two-helix finger to push translocating proteins inside the cytoplasmic funnel of SecY. Cross-linking studies provide further experimental support for this mechanism.

    • Karl J. Erlandson
    • Stephanie B. M. Miller
    • Tom A. Rapoport
    Research
    Nature
    Volume: 455, P: 984-987

  • This study reports the structure of the SecA–SecY complex from bacteria. The structure reveals major conformational changes between both partners and provides novel insights into the path taken by a translocating protein.

    • Jochen Zimmer
    • Yunsun Nam
    • Tom A. Rapoport
    Research
    Nature
    Volume: 455, P: 936-943

  • O GlcNAc transferase (OGT) is an essential mammalian enzyme that glycosylates proteins with O-linked β-N-acetylglucosamine (O-GlcNAc), and this regulates a variety of cellular signalling pathways. Here, the crystal structure of human OGT as a binary complex with UDP and a ternary complex with UDP and a peptide substrate is presented. The structures show how OGT recognizes peptide sequences and provide information on the enzymatic mechanism.

    • Michael B. Lazarus
    • Yunsun Nam
    • Suzanne Walker
    Research
    Nature
    Volume: 469, P: 564-567

  • The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community.

    • Peter A. Meyer
    • Stephanie Socias
    • Piotr Sliz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12