Abscisic acid (ABA), a small-molecule hormone that regulates stress responses in plants, initiates signaling by nucleating ABA receptor–PP2C interactions. A structure-guided approach has produced a class of 3′-S-alkylated ABA derivatives that prevent PP2C binding to ABA receptors by blocking a solvent-exposed channel.
- Jun Takeuchi
- Masanori Okamoto
- Yasushi Todoroki