Nature Search

Energy dissipation in extreme cold

Direct measurements of the energy dissipated by quantum turbulence clearly demonstrate that the scaling of the long-time decay of the energy dissipation in the quasiclassical regime of turbulence differs from that in the ultraquantum regime.

Yuri Sergeev
News & Views01 Jun 2011
Nature Physics

Volume: 7, P: 451-452
Nonlinear light conversion and infrared photodetection with laser-printed plasmonic metasurfaces supporting bound states in the continuum

Laser-printed gold metasurface supporting symmetry-protected plasmonic quasi-bound states in the continuum (qBIC) was fabricated, comprehensively characterized and applied to demonstrate the first qBIC-empowered field-effect transistor device with HgTe quantum dot active medium.

Dmitrii V. Pavlov
Kseniia A. Sergeeva
Andrey L. Rogach
ResearchOpen Access02 Jan 2026
Light: Science & Applications

Volume: 15, P: 1-11
Variants in NR6A1 cause a novel oculo vertebral renal syndrome

Colobomatous microphthalmia often lacks a genetic diagnosis despite its developmental complexity. Here, the authors show that rare variants in NR6A1 cause a syndromic form with eye, kidney, and vertebral defects, supported by zebrafish functional validation.

Uma M. Neelathi
Ehsan Ullah
Brian P. Brooks
ResearchOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Dataset of eye disease-related proteins analyzed using the unfolding mutation screen

Caitlyn L. McCafferty
Yuri V. Sergeev
ResearchOpen Access06 Dec 2016
Scientific Data

Volume: 3, P: 1-10
Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Regulatory B (B_reg) cells producing interleukin-10 (IL-10) suppress autoimmune disease, but the mechanisms mediating their induction remain unclear. Charles E. Egwuagu and colleagues report that IL-35 induces B_reg cells and also promotes their production of IL-35. In vivo IL-35 suppresses autoimmune disease in an IL-35 receptor– and IL-10–dependent manner. Adoptive transfer of IL-35–induced B_reg cells inhibits established autoimmune disease, suggesting that IL-35 and IL-35–producing B_reg cells may be used to treat inflammatory disease.

Ren-Xi Wang
Cheng-Rong Yu
Charles E Egwuagu
Research17 Apr 2014
Nature Medicine

Volume: 20, P: 633-641
In silico Mapping of Protein Unfolding Mutations for Inherited Disease

Caitlyn L. McCafferty
Yuri V. Sergeev
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

Lysosomes maintain RPE health via TFEB/E3-regulated autophagy. Here, the authors show deregulated AKT2/SIRT5/TFEB signaling in the RPE inhibits both lysosomal and mitochondrial function and leads to AMD, suggesting this pathway might provide a therapeutic target for AMD.

Sayan Ghosh
Ruchi Sharma
Debasish Sinha
ResearchOpen Access21 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Global computational mutagenesis of domain structures associated with inherited eye disease

Francisca Wood Ortiz
Yuri V. Sergeev
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Resonant X-ray excitation of the nuclear clock isomer ⁴⁵Sc

Resonant X-ray excitation of the ⁴⁵Sc nuclear isomeric state was achieved by irradiation of a Sc-metal foil with 12.4-keV photon pulses from a state-of-the-art X-ray free-electron laser, allowing a high-precision determination of the transition energy.

Yuri Shvyd’ko
Ralf Röhlsberger
Tomasz Kolodziej
ResearchOpen Access27 Sept 2023
Nature

Volume: 622, P: 471-475
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

Goncalo Abecasis and colleagues report identification of a rare coding variant in the complement 3 gene that is associated with age-related macular degeneration.

Xiaowei Zhan
David E Larson
Goncalo R Abecasis
Research15 Sept 2013
Nature Genetics

Volume: 45, P: 1375-1379
CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability

Yuriko Minegishi
XunLun Sheng
Takeshi Iwata
ResearchOpen Access20 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration

Miyagishima et al. investigate the pathological mechanisms underlying mutant CTRP5 function in late-onset retinal degeneration (L-ORD). With human iPSC-derived RPE cells, they demonstrate that in L-ORD iRPE, constitutive activation of AMPK disrupts cellular metabolism/energy homoeostasis, changes apical/basal VEGF secretion, and Metformin treatment corrects these associated phenotypes.

Kiyoharu J. Miyagishima
Ruchi Sharma
Kapil Bharti
ResearchOpen Access09 Dec 2021
Communications Biology

Volume: 4, P: 1-16
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in mice, suggesting the possibility that the interaction between βA1-PTP1B may be targeted for diabetic retinopathy.

Sayan Ghosh
Haitao Liu
Debasish Sinha
ResearchOpen Access24 Feb 2021
Communications Biology

Volume: 4, P: 1-19
βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin network disruption which leads to polarity disruption and degeneration through PITP β/PLC signaling.

Peng Shang
Nadezda Stepicheva
Debasish Sinha
ResearchOpen Access08 Jul 2021
Communications Biology

Volume: 4, P: 1-14

Search

Energy dissipation in extreme cold

Nonlinear light conversion and infrared photodetection with laser-printed plasmonic metasurfaces supporting bound states in the continuum

Variants in NR6A1 cause a novel oculo vertebral renal syndrome

Dataset of eye disease-related proteins analyzed using the unfolding mutation screen

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

In silico Mapping of Protein Unfolding Mutations for Inherited Disease

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

Global computational mutagenesis of domain structures associated with inherited eye disease

Resonant X-ray excitation of the nuclear clock isomer ⁴⁵Sc

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability

AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

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