Wobble‑position tRNA modifications support accurate decoding, but how cells regulate them is unclear. Here, the authors identify xm5h2U, an oxidized form of xm5s2U, in mammals and show these impair aminoacylation and codon recognition, revealing a stress‑responsive mechanism controlling translation.
- Yufeng Mo
- Kensuke Ishiguro
- Tsutomu Suzuki
