MK2/3 kinases are both highly expressed in the hippocampus and cortex of the brain, but their role is unclear. Here Eales et al.show that MK2/3 signalling regulates dendritic spine morphology and is required for synaptic plasticity via the regulation of AMPA receptor trafficking, and cognitive processes.
- Katherine L. Eales
- Oleg Palygin
- Sonia A.L. Corrêa
