Aging-related immune alteration has been attributed to increased susceptibility to infection and cancer. Here the authors show, using both lung cancer samples and mouse models, that aged Treg cells express higher levels of an ER enzyme, SOAT2, have altered cholesterol metabolism, and induce CD8+ T cell senescence to dampen anti-tumor immunity.
- Mingjiong Zhang
- Jiahua Cui
- Jianqing Wu
