Supramolecular chiral emergence from achiral molecules is studied using newly designed amphiphilic polypeptides upon self-assembling into nanosheets and vesicles in water. The polypeptide, SL-π-D, contains a hydrophilic poly(Sar) block, two hydrophobic helical blocks, and a π-conjugate block. The helical blocks possess right- and left-handed helices, compensating for helical chirality resulting in an achiral molecule. SL-π-D self-assembled in trifluoroethanol/water solutions into uniform nanosheets and vesicles, with the Cotton effect appearing in the achiral π-conjugate block. Supramolecular chiral emergence intrinsically arises from the molecular structure and is enhanced in vesicular morphology.
- Yuya Yoshimoto
- Yuya Suzuki
- Hirotaka Uji
