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Showing 1–21 of 21 results
Advanced filters: Author: Yvette Hooks Clear advanced filters

  • Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

    • Gabriel Balmus
    • Delphine Larrieu
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of Rad50 at the base of the MR structure, and reveal MR head domain oligomerization is required for efficient DNA end resection.

    • Vera M. Kissling
    • Giordano Reginato
    • Matthias Peter
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Viral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that accompany virion maturation, documenting how the dissociation of scaffold proteins and DNA packaging processes intersect.

    • Athanasios Ignatiou
    • Sandrine Brasilès
    • Elena V. Orlova
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Christian Klug et al. have re-examined the Early Carboniferous coleoid Gordoniconus beargulchensis by Reflectance Transformation Imaging, various lights and synchrotron revealing new anatomical details. They discuss evolutionary scenarios of how conchs became internalized, as well as the timing of other important steps in early coleoid evolutionary.

    • Christian Klug
    • Neil H. Landman
    • René Hoffmann
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-12

  • The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with the auto-polymerization and intra-ER accumulation of the Z-A1AT protein, thus highlighting potentially targetable domains.

    • Natalia Brzozowska
    • Lily Y. D. Wu
    • Matthew Hoare
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 875-883

  • Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influences on the somatic evolution of the gastric epithelium.

    • Tim H. H. Coorens
    • Grace Collord
    • Michael R. Stratton
    ResearchOpen Access
    Nature
    Volume: 640, P: 418-426

  • Whole-genome sequencing analysis of somatic mutations in liver samples from patients with chronic liver disease identifies driver mutations in metabolism-related genes such as FOXO1, and shows that these variants frequently exhibit convergent evolution.

    • Stanley W. K. Ng
    • Foad J. Rouhani
    • Peter J. Campbell
    Research
    Nature
    Volume: 598, P: 473-478

  • Whole-genome sequencing of haematopoietic colonies from human fetuses reveals the somatic mutations acquired by individual progenitors, which are used as barcodes to construct a phylogenetic tree of blood development.

    • Michael Spencer Chapman
    • Anna Maria Ranzoni
    • Ana Cvejic
    Research
    Nature
    Volume: 595, P: 85-90

  • The authors report the mutational landscape of 29 cell types from microdissected biopsies from 19 organs and explore the mechanisms underlying mutation rates in normal tissues.

    • Luiza Moore
    • Alex Cagan
    • Raheleh Rahbari
    Research
    Nature
    Volume: 597, P: 381-386

  • Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with the lifespan of the animal across species.

    • Alex Cagan
    • Adrian Baez-Ortega
    • Iñigo Martincorena
    ResearchOpen Access
    Nature
    Volume: 604, P: 517-524

  • Whole-genome sequencing of liver microdissections from five healthy individuals and nine with cirrhosis demonstrates the effects of liver disease on the genome, including increased rates of mutation, complex structural variation and different mutational signatures.

    • Simon F. Brunner
    • Nicola D. Roberts
    • Peter J. Campbell
    Research
    Nature
    Volume: 574, P: 538-542

  • Whole-genome sequencing of normal human endometrial glands shows that most are clonal cell populations and frequently carry cancer driver mutations that occur early in life, and that parity has a protective effect.

    • Luiza Moore
    • Daniel Leongamornlert
    • Michael R. Stratton
    Research
    Nature
    Volume: 580, P: 640-646

  • The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.

    • Thomas R. W. Oliver
    • Lia Chappell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

    • Natasha A. Karp
    • Jeremy Mason
    • Jacqueline K. White
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12